ALL SERVICES AT A GLANCE

Welcome to All Services. On this page you will find all our products and services at a glance.

Additionally, there is a checklist of some general topics for your project planning. You are of course welcome to contact us. If you are looking for more information, please feel free to start a conversation.

Product Sheets:

General toxicology

• Dose range finding
• Single dose toxicity study / Extended single dose toxicity
• Repeated dose toxicity studies
• Local tolerance testing (in vivo)
• Target animal safety studies

Genotoxicity

• Bacterial reverse mutation test (Ames test)
• Mammalian erythrocyte micronucleus test
• XTT cytotoxicity assay
• Colony forming assay in V79 cells
• In vitro mammalian cell gene mutation assay
• Mammalian chromosome aberation test

Safety pharmacology studies

• Safety pharmacology core battery: Nervous system
• Safety pharmacology core battery: Respiratory system
• Safety pharmacology core battery: Cardiovascular system

Irritation and Delayed-type Hypersensitivity 

• Magnusson and Kligmann maximisation test
• Local lymph node assay in the mouse
• Intracutaneous reactivity in the rabbit
• Skin irritation test in the rabbit (single and repeated exposure) / medical device
• Acute skin irritation test in the rabbit
• Acute eye irritation test in the rabbit
• Immediate hypersensitivity reaction (IHR) / Passive Cutaneous Anaphylaxis (PCA)
• Local effects after implantation of medical device

Immunotoxicity

• Immunotoxicological evaluation within toxicity studies
• Anti-drug antibody assay (ADA)
• Immunohistochemistry of immune tissues
• Measurement of protein/nucleic acid level with ELISA
• Measurement of protein/nucleic acid level with Luminex Multiplex Assay
• T-cell dependent antibody response (TDAR)
• Cytotoxic T-cell (CTL) function assay
• Natural killer cell (NK) activity assay
• Immunocell phenotyping
• Cytokine release assay
• In vitro T-cell proliferation assay
• Complement dependent cytotoxicity (CDC)
• Antibody dependent cell-mediated cytotoxicity (ADCC)

Batch realease testing

• In vitro potency assay of the expression level of protein of interest
• In vitro potency assay of the infectivity of an oral vaccine

Other in vitro tests / standard and special services

• Hemolysis assay
• Coagulation assay
• ELISA method transfer/development and validation
• Immunohistochemical analysis
• Tissue cross reactivity
• Local effects after implantation of medical device

Pharmacokinetic studies

• Single and multiple dose pharmacokinetic studies
• Bioequivalence studies in animals
• Pharmacokinetic support of pharmacological/toxicity studies
• Bioavailability study
• In vitro plasma protein-binding
• CaCo-2 transmembrane permeability/ efflux assay
• Providing blank samples for bioanalytical activity

Tissue distribution

• Tissue distribution study with non-radiolabeled test items

Metabolism studies

• In vitro metabolic stability
• In vitro inter-species comparison of metabolism
• In vitro and in vivo metabolic profiling
• Tentative metabolite identification

Bioanalytical activities

• Bioanalytical method development
• Bioanalytical method validation
• Bioanalytical part of toxicokinetic studies
• Bioanalytical support of clinical trials

Quality control activities

• Formulation analysis of dose formulations in toxicity studies
• Formulation analytical method development
• Formulation analytical method validation
• Support for formulation development

Pharmacodynamics

• Wound healing in db/db mice or in Zucker-rat
• Wound healing in the (mini) pig
• Euglycemic clamp test
• Glucose tolerance test

Laboratory services

• Histopathology
• Luminex
• FACS
• ELISA
• Bioanalysis (HPLC, LC/MS/MS…)
• Clinical pathology

---